![]() ![]() In recent years, a man from California has been cured of HIV after his diagnosis in 1988, while Timothy Ray Brown, known as the Berlin Patient, was cured in 2007 - but later died from cancer. The Nature Medicine journal has published the study. "Further research is now needed into how this can be made possible outside the narrow set of framework conditions we have described." "On the one hand, we have the extensive depletion of the virus reservoir in long-lived immune cells, and on the other hand, the transfer of HIV resistance from the donor immune system to the recipient, ensuring that the virus has no chance to spread again. On behalf of the international team, Dr Bjorn-Erik Ole Jensen said: "Following our intensive research, we can now confirm that it is fundamentally possible to prevent the replication of HIV on a sustainable basis by combining two key methods. In 2018, after constant monitoring by doctors, the anti-viral HIV therapy - which had ensured any residual HIV was kept under control up to that point - was ended. The Dusseldorf patient was diagnosed with acute myeloid leukaemia (AML), a form of life-threatening blood cancer, six months after starting his HIV therapy, and underwent the stem cell transplant in 2013. How new technology helped a stroke survivor move her hand for first time in nine years Research should now be continued, experts suggest, to help HIV patients overcome infections without the need for this kind of strenuous intervention in the future. The team, led by medics at Dusseldorf University Hospital, hope the information they have gained will help more studies into cures for HIV. That increases the chance that people of color can benefit from the treatment.Researchers say the virus not returning is the result of thorough scientific and therapeutic preparation and monitoring, adding that the study is the longest and most precise diagnostic monitoring of a patient following a stem cell transplantation.Ī transplant destroys any unhealthy blood cells and replaces them with healthy ones removed from blood or bone marrow, and due to their high risk, are only carried out within the framework of treating other life-threatening conditions. Umbilical cord blood transplants need less similarity between donor and patient. At the time, Wensing called that apparent success good news, especially for patients of color. Where the three European patients received a bone marrow transplant, the American woman was treated with umbilical cord blood. Last year scientists announced that a patient in America seemed to be cured of the virus. The scientists hope that the knowledge gained through the Dusseldorf patient will provide further starting points for HIV studies so less extreme cures can be found in the future. Stem cell transplantation can only be done as part of the treatment of a life-threatening disease like leukemia, the researchers said. The “Berlin patient” and “London patient” preceded him. ![]() The patient is receiving treatment at a hospital in Dusseldorf and is therefore referred to as the “Dusseldorf patient.” He is the third European officially cured of HIV after a stem cell transplant. The mutilation mainly occurs in white people from Central and Northern Europe. The donor’s stem cells lack an attachment site for HIV, which offers protection against the virus. To also tackle the HIV during the stem cell treatment, the researchers used cells from a donor with a genetic mutation. This European cooperation program researches patients with HIV who need a stem cell transplant for a condition like leukemia. The patient participated in the UMC Utrecht-led program IciStem. A woman living with HIV in the United States may be the first female and third person to have been cured of HIV through stem cell transplants. The case has now been published in the Nature Medicine journal. UMC Utrecht researcher Anne Wensing previously mentioned him as one of the virus-free HIV patients, but he has been followed for such a long time now that the researchers can say with great certainty that he has really been cured of the virus. The man received the stem cell transplant almost ten years ago and has been living in good health for four years now without any treatment for HIV. The HIV disappeared after the patient had a stem cell transplant for leukemia, blood cancer. A 53-year-old European man has been declared cured of HIV by an international team of researchers, UMC Utrecht reports.
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